Ciprofloxacin activity in cyst fluid from polycystic kidneys
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چکیده
منابع مشابه
In vitro fluid secretion by epithelium from polycystic kidneys.
The size of the kidneys in patients with autosomal dominant polycystic kidney disease (ADPKD) is due in large measure to the accumulation of secreted fluid within thin-walled epithelial sacs. We measured the net transepithelial movement of liquid in response to forskolin in isolated, intact cysts excised from the surface of human ADPKD kidneys and in cultured, polarized monolayers of epithelial...
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LAMININ 5 REGULATES POLYCYSTIC KIDNEYS CELL PROLIFERATION AND CYST FORMATION Dominique Joly, Sophie Berissi, Amélie Bertrand, Laetitia Strehl, Natacha Patey and Bertrand Knebelmann. From Université Paris-Descartes, Faculté de Médecine ; Inserm U813; AP-HP Hôpital Necker-Enfants-Malades, Paris, France Address correspondance to : Bertrand KNEBELMANN, Department of Nephrology, Hôpital Necker-Enfan...
متن کاملErythropoietin in polycystic kidneys.
Erythropoietin (EPO) formation in kidneys of 18 patients with autosomal dominant polycystic kidney disease (ADPKD) was investigated. In 12 patients on hemodialysis and in 6 patients with preterminal renal failure serum, EPO was 29 +/- 7 and 16 +/- 1.5 mU/ml and hemoglobin concentrations were 11.0 +/- 0.6 and 12.7 +/- 1.2 g/dl, respectively. Cyst fluid from a total of 357 renal cysts was obtaine...
متن کاملAltered synthesis and intracellular transport of proteoglycans by cyst-derived cells from human polycystic kidneys.
Employing in vitro pulse-chase techniques, we investigated the de novo synthesis and the kinetics of intracellular transport and extracellular matrix incorporation of proteoglycans (PG) by normal human renal epithelial cell and by epithelial cells isolated from cysts of autosomal dominant kidneys (ADPKD). Cell monolayers were pulsed either with (3H)leucine for 15 min and chased for seven interv...
متن کاملGene profiling of polycystic kidneys.
BACKGROUND While the genetic basis of autosomal dominant polycystic kidney disease (ADPKD) has been clearly established, the pathogenesis of renal failure in ADPKD remains elusive. Cyst formation originates from proliferating renal tubular epithelial cells that de-differentiate. Fluid secretion with cyst expansion and reactive changes in the extracellular matrix composition combined with increa...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1988
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.32.6.844